Emerging role of mRNA epitranscriptomic regulation in chemoresistant cancer cells

Cancer persister cells remain a significant barrier to effective anti-cancer therapy. We found that melanoma persister cells undergo a reversible reprogramming of mRNA translation. A subset of mRNAs, harboring N6-methyladenosine in their 5ʹ-untranslated regions, is translationally up-regulated in an...

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Bibliographic Details

Published in:	Molecular & Cellular Oncology
Main Authors:	Shensi Shen, Xiaoxiao Sun
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-05-01
Subjects:	cancer persister cell mrna translation epitranscriptomic
Online Access:	http://dx.doi.org/10.1080/23723556.2020.1728467