IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration

Diabetogenic T cells infiltrate the pancreatic islets by transmigrating across the microcapillaries residing close to, or within, the pancreatic islets. Deficiency in IFNγ signaling prevents efficient migration of T cells into the pancreatic islets, but the IFNγ-regulated molecules that mediate this...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Nicholas A. Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Stuart I. Mannering, Thomas W. H. Kay, Helen E. Thomas
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Subjects:	Type 1 diabetes MHC class II interferon-γ endothelial cells non-obese diabetic mice
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02800/full