Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis

Background: Natural Killer T (NKT) cells are CD1d-restricted innate-like T cells that can rapidly release stored cytokines upon recognition of lipid antigens. In mice, type I NKT cells seem to promote liver inflammation, whereas type II NKT cells seem to restrict hepatitis. Here, we aimed at charact...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Marcial Sebode, Jennifer Wigger, Pamela Filpe, Lutz Fischer, Sören Weidemann, Till Krech, Christina Weiler-Normann, Moritz Peiseler, Johannes Hartl, Eva Tolosa, Johannes Herkel, Christoph Schramm, Ansgar W. Lohse, Philomena Arrenberg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-05-01
Subjects:	alpha-galactosylceramide CD1d lipid antigen tumor necrosis factor-alpha unconventional T cells
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01065/full