Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases

p97/VCP, a highly conserved type II ATPase associated with diverse cellular activities (AAA+ ATPase), is an important therapeutic target in the treatment of neurodegenerative diseases and cancer. p97 performs a variety of functions in the cell and facilitates virus replication. It is a mechanochemic...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Sepideh Valimehr, Ashish Sethi, Manjari Shukla, Sudipta Bhattacharyya, Mohsen Kazemi, Isabelle Rouiller
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	p97-VCP ATPase cryo-electron microscopy
Online Access:	https://www.mdpi.com/2218-273X/13/5/737