Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

IntroductionPhenobarbital (PB) remains the first-line treatment for canine epilepsy due to its efficacy, affordability, and favorable pharmacokinetics. However, its narrow therapeutic index and substantial interindividual variability necessitate therapeutic drug monitoring (TDM) and individualized d...

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出版年:	Frontiers in Veterinary Science
主要な著者:	Silvana Alvariza, Manuel Ibarra, Natalia Guevara, Cecilia Maldonado, Marta Vázquez, Gimena Feijoó, Gonzalo Suárez
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2025-09-01
主題:	phenobarbital population pharmacokinetics therapeutic drug monitoring model-informed precision dosing canine epilepsy
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fvets.2025.1644003/full