Inactivation of NLRP3 inflammasome by dephosphorylation at Serine 658 alleviates glial inflammation in the mouse model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a leading neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, contributing to considerable disability worldwide. Current treatments offer only symptomatic relief, highlighting the need for novel therapeutic strateg...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Rong-Xin Zhu, Rui-Xue Han, Yue-Han Chen, Lei Huang, Ting Liu, Jingwei Jiang, Cong Wang, Lei Cao, Yang Liu, Ming Lu
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	NLRP3 inflammasome Phosphorylation Serine 658 Inflammation Parkinson’s disease
Online Access:	https://doi.org/10.1186/s13024-025-00818-z