Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies

Aseptic loosening (AL) represents the leading cause of long-term failure in total joint arthroplasty, often necessitating revision surgery. This review explores the complex mechanisms underlying AL, which involve a multifaceted interaction between the implanted biomaterials and the host immune respo...

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Bibliographic Details

Published in:	Applied Sciences
Main Authors:	Gabriele Ricciardi, Lorenza Siracusano, Edoardo Micale, Vito Addorisio, Mariagiovanna Ballato, Domenico Donadio, Pietro Tralongo, Giuseppe Giuffrè, Danilo Leonetti, Maurizio Martini, Biagio Zampogna
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	aseptic loosening biomarker osteolysis total hip arthroplasty
Online Access:	https://www.mdpi.com/2076-3417/15/16/9156