Phosphoenolpyruvate carboxylase (PEPC) is essential for the glycolytic pathway and parasite proliferation in Babesia gibsoni

Abstract Apicomplexan parasites predominantly generate ATP and lactic acid through glycolysis and anaerobic glucose metabolism, incorporating CO2 into glycolysis via a stage-dependent phosphoenolpyruvate carboxylase (PEPC) mechanism. Although the role of PEPC in plant and bacterial carbon fixation i...

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Bibliographic Details

Published in:	Animal Diseases
Main Authors:	Dong-Fang Li, Ling-Na Wang, Yi-Dan Bai, Yu-Xin Yu, Xing Lu, Xing-Ai Guan, Fang-Jie Li, Sen Wang, Lan He, Jun-Long Zhao
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	Babesia gibsoni Phosphoenolpyruvate Phosphoenolpyruvate carboxylase Malate Aspartate
Online Access:	https://doi.org/10.1186/s44149-024-00148-5