IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy

Summary: Microglia shift toward an inflammatory phenotype during aging that is thought to exacerbate age-related neurodegeneration. The molecular and cellular signals that resolve neuroinflammation post-injury are largely undefined. Here, we exploit systems genetics methods based on the extended BXD...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Li Pan, Kin-Sang Cho, Xin Wei, Fuyi Xu, Anton Lennikov, Guangan Hu, Jing Tang, Shuai Guo, Julie Chen, Emil Kriukov, Robert Kyle, Farris Elzaridi, Shuhong Jiang, Pierre A. Dromel, Michael Young, Petr Baranov, Chi-Wai Do, Robert W. Williams, Jianzhu Chen, Lu Lu, Dong Feng Chen
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Subjects:	CP: Neuroscience CP: Immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723009002