GenX induces offspring vascular endothelial ferroptosis by targeting GPX4 for ubiquitination-dependent degradation

GenX, a widely used replacement for PFOA, has become ubiquitously distributed in aquatic ecosystems, soil, and biota, yet its developmental toxicity in offspring is poorly characterized. This study delineates the intergenerational vascular consequences of gestational GenX exposure. Pregnant mice exp...

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Bibliographic Details

Published in:	Current Research in Toxicology
Main Authors:	Jing Li, Yuhui Cui, Chengyi Zheng, Yiwei Zhang, Shuxian Li, Lingbing Li
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	GenX Placenta Vascular endothelial cell Ferroptosis GPX4
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666027X25000465