Au(III) Schiff base complexes as oxidoreductase inhibitors against carbapenem- and colistin-resistant Gram-negative bacteria via targeting redox active motifs

Carbapenem- and colistin-resistant Gram-negative bacteria have become one of the most severe public health issues worldwide. The development of advanced antibacterial agents that can outpace microbial adaptation is imperative. The thioredoxin (Trx) and glutaredoxin (Grx) systems play important roles...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Xiuli Chen, Lin Lv, Jianqiang Xu, Jing Shi, Xi Chen, Guisha Zi, Yuxuan Wu, Shibo Sun, Yufan Pang, Qian Song, Ling Ma, Shuang Wei, Tonghui Ma, Wukun Liu
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Au(III) Schiff base complexes Glutathione reductase Thioredoxin reductase Redox imbalance Multi-target pathway Drug-resistant bacteria
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725003131