Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort

Abstract Background For clinical implementation of Alzheimer’s disease (AD) blood-based biomarkers (BBMs), knowledge of short-term variability, is crucial to ensure safe and correct biomarker interpretation, i.e., to capture changes or treatment effects that lie beyond that of expected short-term va...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Alzheimer’s disease biomarkers Blood-based biomarkers Memory clinic cohort Short-term variability Intra- and Inter-individual variability, Reference change value (RCV), Plasma Aβ42/Aβ40 ratio, Phosphorylated tau (p-tau), Neurofilament light (NfL), Glial fibrillary acidic protein (GFAP)
Online Access:	https://doi.org/10.1186/s13195-024-01658-7