Augmenting control arms with real-world data for cancer trials: Hybrid control arm methods and considerations

Background: Hybrid controlled trials with real-world data (RWD), where the control arm is composed of both trial and real-world patients, could facilitate research when the feasibility of randomized controlled trials (RCTs) is challenging and single-arm trials would provide insufficient information....

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Bibliographic Details

Published in:	Contemporary Clinical Trials Communications
Main Authors:	W. Katherine Tan, Brian D. Segal, Melissa D. Curtis, Shrujal S. Baxi, William B. Capra, Elizabeth Garrett-Mayer, Brian P. Hobbs, David S. Hong, Rebecca A. Hubbard, Jiawen Zhu, Somnath Sarkar, Meghna Samant
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Subjects:	Hybrid control arms External comparator cohorts Real-world data
Online Access:	http://www.sciencedirect.com/science/article/pii/S245186542200117X