Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages

Summary: A wide variety of electrophilic derivatives of itaconate, the Kreb’s cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities. Therefore, we generated a genetic system to interrogate the immunomodulatory functions of endog...

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出版年:	Cell Reports
主要な著者:	Luke A. Bourner, Linda A. Chung, Haiyan Long, Anne F. McGettrick, Junpeng Xiao, Kenneth Roth, Jade D. Bailey, Marie Strickland, Bo Tan, Jason Cunningham, Barry Lutzke, James McGee, Francella J. Otero, David C. Gemperline, Lin Zhang, Ying C. Wang, Michael J. Chalmers, Chiao-Wen Yang, Jesus A. Gutierrez, Luke A.J. O’Neill, Frank C. Dorsey
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2024-08-01
主題:	CP: Immunology
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124724008994