Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages

Summary: A wide variety of electrophilic derivatives of itaconate, the Kreb’s cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities. Therefore, we generated a genetic system to interrogate the immunomodulatory functions of endog...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Cell Reports
المؤلفون الرئيسيون:	Luke A. Bourner, Linda A. Chung, Haiyan Long, Anne F. McGettrick, Junpeng Xiao, Kenneth Roth, Jade D. Bailey, Marie Strickland, Bo Tan, Jason Cunningham, Barry Lutzke, James McGee, Francella J. Otero, David C. Gemperline, Lin Zhang, Ying C. Wang, Michael J. Chalmers, Chiao-Wen Yang, Jesus A. Gutierrez, Luke A.J. O’Neill, Frank C. Dorsey
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2024-08-01
الموضوعات:	CP: Immunology
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2211124724008994

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