Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease

The purpose of our study is to investigate early cellular, molecular, morphological and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month-old homozygous hAbKI mice, we studied behavioral phenotype parameters, including spatial learning and memory (Morris Water Maz...

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發表在:	Cells
Main Authors:	Sudhir Kshirsagar, Rainier Vladlen Alvir, Ashly Hindle, Subodh Kumar, Murali Vijayan, Jangampalli Adi Pradeepkiran, Arubala P. Reddy, Bhagavathi Ramasubramanian, P. Hemachandra Reddy
格式:	Article
語言:	英语
出版:	MDPI AG 2022-02-01
主題:	amyloid beta mitochondria late-onset Alzheimer’s disease dendritic spines
在線閱讀:	https://www.mdpi.com/2073-4409/11/4/733