Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide

An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.

Bibliographic Details

Published in:	Beilstein Journal of Organic Chemistry
Main Authors:	Dongming Zhang, Bin Lv, Pan Gao, Xiaodong Jia, Yu Yuan
Format:	Article
Language:	English
Published:	Beilstein-Institut 2022-06-01
Subjects:	amination copper n-hydroxyphthalimides radical reactions triethyl phosphite
Online Access:	https://doi.org/10.3762/bjoc.18.65