Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.
| Published in: | Beilstein Journal of Organic Chemistry |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2022-06-01
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| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.18.65 |
| _version_ | 1851890288610508800 |
|---|---|
| author | Dongming Zhang Bin Lv Pan Gao Xiaodong Jia Yu Yuan |
| author_facet | Dongming Zhang Bin Lv Pan Gao Xiaodong Jia Yu Yuan |
| author_sort | Dongming Zhang |
| collection | DOAJ |
| container_title | Beilstein Journal of Organic Chemistry |
| description | An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite. |
| format | Article |
| id | doaj-art-55d7dd16d10d4f09ba28fa916a2acaf4 |
| institution | Directory of Open Access Journals |
| issn | 1860-5397 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| spelling | doaj-art-55d7dd16d10d4f09ba28fa916a2acaf42025-08-19T22:09:53ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972022-06-0118164765210.3762/bjoc.18.651860-5397-18-65Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromideDongming Zhang0Bin Lv1Pan Gao2Xiaodong Jia3Yu Yuan4College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.https://doi.org/10.3762/bjoc.18.65aminationcoppern-hydroxyphthalimidesradical reactionstriethyl phosphite |
| spellingShingle | Dongming Zhang Bin Lv Pan Gao Xiaodong Jia Yu Yuan Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide amination copper n-hydroxyphthalimides radical reactions triethyl phosphite |
| title | Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide |
| title_full | Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide |
| title_fullStr | Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide |
| title_full_unstemmed | Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide |
| title_short | Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide |
| title_sort | direct c h amination reactions of arenes with n hydroxyphthalimides catalyzed by cuprous bromide |
| topic | amination copper n-hydroxyphthalimides radical reactions triethyl phosphite |
| url | https://doi.org/10.3762/bjoc.18.65 |
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