Systematic design of DMBT1-derived peptides correlating physicochemical properties and sequence motifs with siRNA delivery and efficacy in cancer therapyResearch in context

Summary: Background: Molecules driving the cancer process are frequently difficult to target with traditional small-molecule drugs. Small interfering RNAs (siRNAs) offer high specificity, but their clinical translation is hindered by inefficient delivery and rapid degradation. We previously identif...

Full description

Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Martina Tuttolomondo, Mikkel Green Terp, Nazmie Kalisi, Stefan Vogel, Henrik Jørn Ditzel
Format:	Article
Language:	English
Published:	Elsevier 2025-11-01
Subjects:	Cell-penetrating peptides siRNA RNA interference Cancer therapy DMBT1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396425004219