Introduction of Mercaptoethyl at Sorafenib Pyridine-2-Amide Motif as a Potentially Effective Chain to Further get Sorafenib-PEG-DGL

The crystal structure of the sorafenib and B-RAF complex indicates that the binding cavity occupied by the pyridine-2-carboxamide in sorafenib has a large variable space, making it a reasonable modification site. In order to identify novel compounds with anti-cancer activity, better safety and polar...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ke Wang, Kudelaidi Kuerbana, Qi Wan, Zhihui Yu, Li Ye, Ying Chen
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Subjects:	sorafenib analogs antiproliferation nanoparticles (nps) molecular modeling
Online Access:	https://www.mdpi.com/1420-3049/25/3/573