Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons

Abstract Background The G2019S mutation of LRRK2, which enhances kinase activity of the protein, confers a substantial risk of developing Parkinson’s disease (PD). However, the mutation demonstrates incomplete penetrance, suggesting the involvement of other genetic or environmental modulating factor...

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Bibliographic Details

Published in:	BMC Neuroscience
Main Authors:	Hoang Kieu Chi Ngo, Akriti Srivastava, Hoang Le, Samuel J. Ayer, Grace F. Crotty, Michael A. Schwarzschild, Rachit Bakshi
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Parkinson’s disease Dopaminergic neuronal loss LRRK2 G2019S Autophosphorylaton LPS
Online Access:	https://doi.org/10.1186/s12868-025-00939-7