Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours

Abstract Background Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection. While the tumour microenvironment...

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Bibliographic Details

Published in:	Genome Medicine
Main Authors:	Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, S. Y. Cindy Yang, David T. Mulder, Jeffrey P. Bruce, Joseph N. Paulson, Pichai Raman, Yuankun Zhu, Adam C. Resnick, Poul H. Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D. Johann, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Natalie Jäger, Trevor J. Pugh
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Paediatric neuro-oncology Immunogenomics CNS tumours Tumour microenvironment Neuroblastoma
Online Access:	https://doi.org/10.1186/s13073-023-01219-x