Understanding the Targeting Mechanisms of Multi-Specific Biologics in Immunotherapy with Multiscale Modeling

Summary: Immunotherapeutics are frequently associated with adverse side effects due to the elicitation of global immune modulation. To lower the risk of these side effects, recombinant DNA technology is employed to enhance the selectivity of cell targeting by genetically fusing different biomolecule...

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Bibliographic Details

Published in:	iScience
Main Authors:	Zhaoqian Su, Bo Wang, Steven C. Almo, Yinghao Wu
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Subjects:	Immunology Therapeutics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220310324