Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats

Background. This study was to explore the pharmacokinetics of saxagliptin (Sax) in Goto–Kakizaki (GK) rats complicated with depression induced by chronic unpredicted mild stress (CUMS). The comorbidity of diabetic patients with depression is becoming more and more epidemic. Whether depression mental...

詳細記述

書誌詳細

出版年:	PeerJ
主要な著者:	Zhengchao Xia, Hongyan Wei, Jingjing Duan, Ting Zhou, Zhen Yang, Feng Xu
フォーマット:	論文
言語:	英語
出版事項:	PeerJ Inc. 2016-01-01
主題:	Pharmacokinetics Depression Diabetes CUMS Saxagliptin Rat
オンライン･アクセス:	https://peerj.com/articles/1611.pdf