Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis

Plasma membrane (PM) free cholesterol (FC) is emerging as an important modulator of signal transduction. Here, we show that hepatocyte-specific knockout (HSKO) of the cellular FC exporter, ATP-binding cassette transporter A1 (ABCA1), leads to decreased PM FC content and defective trafficking of lyso...

詳細記述

書誌詳細

出版年:	Cell Reports
主要な著者:	Chia-Chi C. Key, Mingxia Liu, C. Lisa Kurtz, Soonkyu Chung, Elena Boudyguina, Timothy A. Dinh, Alexander Bashore, Peter E. Phelan, Barry I. Freedman, Timothy F. Osborne, Xuewei Zhu, Lijun Ma, Praveen Sethupathy, Sudha B. Biddinger, John S. Parks
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2017-06-01
主題:	hepatosteatosis cholesterol lipid raft vesicle trafficking selective insulin resistance mTORC plasma membrane hepatocyte Western-type diet
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124717306745