Cystatin C alleviates unconjugated bilirubin-induced neurotoxicity by promoting bilirubin clearance from neurocytes via exosomes, dependent on hepatocyte UGT1A1 activity

There is an urgent need to identify effective drugs for the treatment of nerve injury caused by unconjugated bilirubin (UCB). Our previous research found that cystatin C (CST3) alleviates UCB-induced neurotoxicity by promoting autophagy in nerve cells, but that autophagy inhibitors did not completel...

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Bibliographic Details
Published in:Translational Neuroscience
Main Authors: Du Yating, Li Zhenkun
Format: Article
Language:English
Published: De Gruyter 2024-10-01
Subjects:
cystatin c
unconjugated bilirubin
exosome
udp-glucuronyl transferase1a1
Online Access:https://doi.org/10.1515/tnsci-2022-0357

Internet

https://doi.org/10.1515/tnsci-2022-0357

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