Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal InflammationSummary

Background & Aims: Despite recent evidence supporting the metabolic plasticity of CD4+ T cells, it is uncertain whether the metabolic checkpoint pyruvate dehydrogenase kinase (PDK) in T cells plays a role in the pathogenesis of colitis. Methods: To investigate the role of PDK4 in colitis, we...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	Inflammatory Bowel Disease Pyruvate Dehydrogenase Kinase Mitochondria-Associated ER Membrane
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X22002119