Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal InflammationSummary

Background & Aims: Despite recent evidence supporting the metabolic plasticity of CD4+ T cells, it is uncertain whether the metabolic checkpoint pyruvate dehydrogenase kinase (PDK) in T cells plays a role in the pathogenesis of colitis. Methods: To investigate the role of PDK4 in colitis, we...

Full description

Bibliographic Details
Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	Inflammatory Bowel Disease Pyruvate Dehydrogenase Kinase Mitochondria-Associated ER Membrane
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X22002119

Similar Items

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
by: Min-Ji Kim, et al.
Published: (2023-03-01)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
by: Sharma Pushpa, et al.
Published: (2009-01-01)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
by: In-Kyu Lee
Published: (2014-06-01)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
by: Jirair K. Bedoyan, et al.
Published: (2019-07-01)

Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health
by: Vikalp Kumar, et al.
Published: (2025-05-01)

Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4
by: Chang Joo Oh, et al.
Published: (2024-12-01)

Intracellular acetyl phosphate modulates Escherichia coli pyruvate metabolism
by: Zhang Ling, et al.
Published: (2025-05-01)

Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase
by: Mya D. Gough, et al.
Published: (2025-04-01)

Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
by: Ah Reum Khang, et al.
Published: (2024-05-01)

Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
by: Chenyu Li, et al.
Published: (2023-12-01)

The Role of the Pyruvate Dehydrogenase Complex in the Development of Ischemic-Reperfusion Syndrome
by: K. A. Popov, et al.
Published: (2022-08-01)

Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
by: Eri Ogawa, et al.
Published: (2023-06-01)

Genetic Ablation of Pyruvate Dehydrogenase Kinase Isoform 4 Gene Enhances Recovery from Hyperoxic Lung Injury: Insights into Antioxidant and Inflammatory Mechanisms
by: Keisuke Watanabe, et al.
Published: (2024-03-01)

Astrocytic pyruvate dehydrogenase kinase-lactic acid axis involvement in glia-neuron crosstalk contributes to morphine-induced hyperalgesia in mice
by: Xiaqing Ma, et al.
Published: (2024-07-01)

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy
by: Abdallah Elnwasany, et al.
Published: (2023-03-01)

Escherichia coli aceE variants coding pyruvate dehydrogenase improve the generation of pyruvate‐derived acetoin
by: W. Chris Moxley, et al.
Published: (2023-03-01)

Pyruvic Acid Production from Sucrose by <i>Escherichia coli</i> Pyruvate Dehydrogenase Variants
by: W. Chris Moxley, et al.
Published: (2023-05-01)

MiR‐5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer
by: Yongchang Miao, et al.
Published: (2020-10-01)

Perioperative considerations of pyruvate dehydrogenase complex deficiency: a case report of two consecutive anesthesia
by: Won Yong Lim, et al.
Published: (2023-07-01)

Elevated Level of Cerebrospinal Fluid Pyruvate Dehydrogenase Kinase 4 Is a Predictive Biomarker of Clinical Outcome after Subarachnoid Hemorrhage
by: Xuan Gao, et al.
Published: (2022-11-01)

Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress
by: David L. Long, et al.
Published: (2023-09-01)

The Effects of Pyruvate Dehydrogenase Kinase 4 (PDK4) Inhibition on Metabolic Flexibility during Endurance Training in Skeletal Muscles of Streptozotocin-induced Diabetic Rats
by: Hamid Marefati, et al.
Published: (2020-07-01)

Iodine Deficiency Hypothyroidism in Residents of the Prykarpattia Region: Results of the First Phase of the Clinical Examination Using Pyruvate Dehydrogenase and α-ketonuria Tests
by: Tomashevskyy Y., et al.
Published: (2014-06-01)

Effects of zinc oxide nanoparticles on pyruvate dehydrogenase and lactate dehydrogenase expressions and apoptotic index in breast cancer cells
by: Cem ÖZİÇ, et al.
Published: (2024-06-01)

Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome
by: Amanda A. Greenwell, et al.
Published: (2022-09-01)

Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism
by: Filmon Eyassu, et al.
Published: (2017-01-01)

Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation
by: Gonzalo Perez-Siles, et al.
Published: (2016-10-01)

Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis
by: Reinis Rutkis, et al.
Published: (2021-05-01)

Pyruvate dehydrogenase deficiency: morphological and metabolic effects, creation of animal model to search for curative treatment
by: A. Ebertowska, et al.
Published: (2020-06-01)

Long-term use of investigational β-Hydroxybutyrate salts in children with multiple acyl-CoA dehydrogenase or pyruvate dehydrogenase deficiency
by: Andrew A.M. Morris, et al.
Published: (2024-09-01)

Endurance training and pyruvate dehydrogenase kinase 4 (PDK4) inhibition combination is superior to each one alone in attenuating hyperketonemia/ketoacidosis in diabetic rats
by: Hamed Rezaeinasab, et al.
Published: (2025-01-01)

The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism
by: Laure Nicolas Annick Ries, et al.
Published: (2018-07-01)

Waterlogging Tolerance of <i>Actinidia valvata Dunn</i> Is Associated with High Activities of Pyruvate Decarboxylase, Alcohol Dehydrogenase and Antioxidant Enzymes
by: Minxia Gao, et al.
Published: (2023-08-01)

Modification of pyruvate kinase and lactate dehydrogenase in foot muscle of the sea mussel Mytilus galloprovincialis under anaerobiosis and recovery
by: V.I. Lushchak, et al.
Published: (1997-03-01)

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology
by: Gopinath eSutendra, et al.
Published: (2013-03-01)

PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
by: Juhee Kim, et al.
Published: (2024-08-01)

The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum
by: Tao Gao, et al.
Published: (2020-05-01)

Mitochondrial Encephalomyopathy Associated with Pyruvate Dehydrogenase Complex Deficiency: Eight Clinical Cases
by: Ekaterina A. Nikolaeva, et al.
Published: (2021-03-01)

Cellular localization of the hybrid pyruvate/2-oxoglutarate dehydrogenase complex in the actinobacterium Corynebacterium glutamicum
by: Lea Sundermeyer, et al.
Published: (2023-10-01)

Skeletal Muscle Pyruvate Dehydrogenase Phosphorylation and Lactate Accumulation During Sprint Exercise in Normoxia and Severe Acute Hypoxia: Effects of Antioxidants
by: David Morales-Alamo, et al.
Published: (2018-03-01)