Designing a multi-epitope vaccine against Pseudomonas aeruginosa via integrating reverse vaccinology with immunoinformatics approaches

Abstract Pseudomonas aeruginosa is a typically opportunistic pathogen responsible for a wide range of nosocomial infections. In this study, we designed two multi-epitope vaccines targeting P. aeruginosa proteins, incorporating cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and linear B lym...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Fei Zhu, Rongliu Qin, Shiyang Ma, Ziyou Zhou, Caixia Tan, Hang Yang, Peipei Zhang, Yizhong Xu, Yuying Luo, Jie Chen, Pinhua Pan
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Subjects:	Pseudomonas aeruginosa Multi-epitope vaccine Molecular docking Molecular dynamics simulation Reverse vaccinology Immunoinformatics
Online Access:	https://doi.org/10.1038/s41598-025-90226-6