Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo

Background Non-small-cell lung cancer (NSCLC) is one of the deadliest malignancies in the world. Signal transducer and activator of transcription 3 (STAT3) plays an important role in the progression of NSCLC. Bruceine D is a bioactive quassinoid compound extracted from Brucea javanica, a plant widel...

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Published in:	Cancer Biology & Therapy
Main Authors:	Yu Zhu, Xuan Xu, Xiaofan Hong, Jiayi Zhang, Yi Zhou, Aofeng Sun, Yihan Ye, Yini Xu, Huanhai Xu, Haiyang Zhao, Chengguang Zhao, Xing Jin, Lehe Yang, Jianxiao Zheng
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2026-12-01
Subjects:	Bruceine D STAT3 NSCLC glycolysis inhibitor
Online Access:	https://www.tandfonline.com/doi/10.1080/15384047.2026.2665867