Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development

Abstract Tumor cachexia represents a complex and multifaceted metabolic syndrome that profoundly affects the quality of life and survival rates of individuals. It is highly prevalent in advanced cancer patients and is characterized by severe weight loss, muscle wasting, and systemic inflammation. Th...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Guoming Chen, Bonan Chen, Yilin Wu, Hao Nie, Zilan Zhong, Shuyang Yang, Rui Qin, Wei Kang, Cheng Zhang, Ning Wang, Yibin Feng
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Tumor microenvironment (TME) Cachexia Cancer-associated fibroblasts (CAFs)
Online Access:	https://doi.org/10.1186/s12943-025-02379-7