Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms

Abstract Brain takes up approximately 20% of the total body oxygen and glucose consumption due to its relatively high energy demand. Glucose is one of the major sources to generate ATP, the process of which can be realized via glycolysis, oxidative phosphorylation, pentose phosphate pathways and oth...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Yao Wang, Ping Li, Yuan Xu, Linyu Feng, Yongkang Fang, Guini Song, Li Xu, Zhou Zhu, Wei Wang, Qi Mei, Minjie Xie
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Lactate Histone lactylation CNS diseases Inflammation
Online Access:	https://doi.org/10.1186/s12974-024-03303-4