High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting

Next-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications – “amplificators”. We sought to understand the molec...

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發表在:	Cancer Biology & Therapy
Main Authors:	Rushikesh S. Joshi, Amelie Boichard, Jacob J. Adashek, Razelle Kurzrock
格式:	Article
語言:	英语
出版:	Taylor & Francis Group 2022-12-01
主題:	cancer genes next-generation sequencing amplifications tp53
在線閱讀:	http://dx.doi.org/10.1080/15384047.2022.2128608