Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2

Abstract Objective Glioma, a malignant primary brain tumor, is notorious for its high incidence rate. However, the clinical application of temozolomide (TMZ) as a treatment option for glioma is often limited due to resistance, which has been linked to hypoxic glioma cell-released exosomes. In light...

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Bibliographic Details

Published in:	Discover Oncology
Main Authors:	Guofu Li, Ziyu Xiong, Ying Li, Cong Yan, Yingying Cheng, Yuwen Wang, Jingwei Li, Zifeng Dai, Dongdong Zhang, Wenzhong Du, Chunyang Men, Changbin Shi
Format:	Article
Language:	English
Published:	Springer 2024-04-01
Subjects:	Glioma Hypoxia Exosome Pyruvate kinase M2 Temozolomide Resistance
Online Access:	https://doi.org/10.1007/s12672-024-00963-9