Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration

Abstract Overexpression or activation of oncogenes or loss of tumor-suppressor genes can induce cellular senescence as a defense mechanism against tumor development, thereby maintaining cellular homeostasis. However, cancer cells can circumvent this senescent state and continue to spread. Myosin lig...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Dayoung Kim, Jonathan A. Cooper, David M. Helfman
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	Breast cancer Cell migration Myosin light chain kinase Senescence-associated secretory phenotype P21 MTOR
Online Access:	https://doi.org/10.1038/s41598-024-76868-y