Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors

Host defense peptides (HDPs) are an integral part of the innate immune system acting as the first line of defense. Modulation of HDP synthesis has emerged as a promising host-directed approach to fight against infections. Inhibition of histone deacetylation or DNA methylation is known to enhance HDP...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Melanie A. Whitmore, Hong Li, Wentao Lyu, Sharmily Khanam, Guolong Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Subjects:	host defense peptides histone methyltransferase inhibitors DNA methyltransferase inhibitors histone deacetylase inhibitors epigenetic modification
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.874706/full