Activity-Based Proteomics Reveals Heterogeneous Kinome and ATP-Binding Proteome Responses to MEK Inhibition in KRAS Mutant Lung Cancer

One way cancer cells can escape from targeted agents is through their ability to evade drug effects by rapidly rewiring signaling networks. Many protein classes, such as kinases and metabolic enzymes, are regulated by ATP binding and hydrolysis. We hypothesized that a system-level profiling of drug-...

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Bibliographic Details

Published in:	Proteomes
Main Authors:	Jae-Young Kim, Paul A. Stewart, Adam L. Borne, Bin Fang, Eric A. Welsh, Yian Ann Chen, Steven A. Eschrich, John M. Koomen, Eric B. Haura
Format:	Article
Language:	English
Published:	MDPI AG 2016-04-01
Subjects:	adaptive resistance desthiobiotin-ATP probe KRAS mutant lung cancer LC-MS/MS MEK inhibitor
Online Access:	http://www.mdpi.com/2227-7382/4/2/16