The Oncolytic virus VT1092M and an Anti-PD-L1 antibody synergize to induce systemic antitumor immunity in a murine bilateral tumor model

This study investigated the synergistic potential of an oncolytic herpes simplex virus armed with interleukin 12 (VT1092M) in combination with immune checkpoint inhibitors for enhancing antitumor responses. The potential of this combination treatment to induce systemic antitumor immunity was assesse...

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Bibliographic Details

Published in:	Translational Oncology
Main Authors:	Wei Zhu, Mingxia Shao, Chao Tian, Jianshuai Yang, Hua Zhou, Jiajia Liu, Chunyang Sun, Min Liu, Jinyu Wang, Lijun Wei, Shuzhen Li, Xiaopeng Li, Jingfeng Li
Format:	Article
Language:	English
Published:	Elsevier 2024-08-01
Subjects:	Antitumor immunity Immune checkpoint inhibitor Oncolytic virus Interleukin 12 Bilateral tumor model
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523324001475