Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain

In the early stages of the central nervous system growth and development, γ-aminobutyric acid (GABA) plays an instructive trophic role for key events including neurogenesis, migration, synaptogenesis, and network formation. These actions are associated with increased concentration of chloride ions i...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Mira Hamze, Igor Medina, Quentin Delmotte, Christophe Porcher
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Subjects:	GABA KCC2 activity Smo chloride homeostasis Shh
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.798066/full