New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases

The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. The treatment comprises...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Milena Mlakić, Tena Čadež, Danijela Barić, Ivana Puček, Ana Ratković, Željko Marinić, Kornelija Lasić, Zrinka Kovarik, Irena Škorić
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	AChE BChE reactivation heterostilbenes spectroscopy docking
Online Access:	https://www.mdpi.com/1424-8247/14/11/1147