VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage

Ischemia-reperfusion (I/R) injury constitutes a significant risk factor for a range of diseases, including ischemic stroke, myocardial infarction, and trauma. Following the restoration of blood flow post-tissue ischemia, oxidative stress can lead to various forms of cell death, including necrosis, a...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Hao Wan, Yan-di Yang, Qi Zhang, Yu-hua Chen, Xi-min Hu, Yan-xia Huang, Lei Shang, Kun Xiong
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	OGD/R Necroptosis MLKL VDAC1 Mitochondria damage
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844023106347