Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing

Abstract Pancreatic adenocarcinoma (PDAC) is one of the most lethal cancer types worldwide, with early diagnosis being challenging due to nonspecific symptoms that are often noticed only when the tumor reaches a large size. Liquid biopsy has emerged as a promising technology in oncology, where the i...

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出版年:	Scientific Reports
主要な著者:	Anelis Maria Marin, Branca Engel Timoner, Diogo Dias Araújo, Miyuki Uno, Maria José Ferreira Alves, Roger Chammas, Guilherme Naccache Namur, Denise Kusma Wosniaki, Federico Canzian, Lucas Blanes, Dalila Lucíola Zanette, Mateus Nóbrega Aoki
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2026-03-01
主題:	PDAC Pancreatic cancer Liquid biopsy CfDNA NGS
オンライン･アクセス:	https://doi.org/10.1038/s41598-026-42403-4