Making “cold” tumors “hot”- radiotherapy remodels the tumor immune microenvironment of pancreatic cancer to benefit from immunotherapy: a case report

Immune checkpoint inhibitors have limited efficacy in metastatic pancreatic cancer due to the complex tumor immune microenvironment (TIME). Studies have shown that radiotherapy can cause cell lesions to release tumor antigens and then take part in the remodeling of the tumor environment and the indu...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Fan Tong, Yi Sun, Yahui Zhu, Huizi Sha, Jiayao Ni, Liang Qi, Qing Gu, Chan Zhu, Wenjing Xi, Baorui Liu, Weiwei Kong, Juan Du
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Subjects:	immune checkpoint inhibitors tumor immune microenvironment radiotherapy metastatic pancreatic cancer second-line treatment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1277810/full