Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis

Abstract Miner1 is a redox‐active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1−/− mice displayed ER stress and showed hallmarks of the unfolded pro...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Sandra E. Wiley, Alexander Y. Andreyev, Ajit S. Divakaruni, Robert Karisch, Guy Perkins, Estelle A. Wall, Peter van der Geer, Yi‐Fan Chen, Ting‐Fen Tsai, Melvin I. Simon, Benjamin G. Neel, Jack E. Dixon, Anne N. Murphy
Format:	Article
Language:	English
Published:	Springer Nature 2013-05-01
Subjects:	calcium endoplasmic reticulum mitochondria oxidative stress Wolfram Syndrome
Online Access:	https://doi.org/10.1002/emmm.201201429