Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE

Objective Quinolinic acid (QA), a kynurenine (KYN)/tryptophan (TRP) pathway metabolite, is an N-methyl-D-aspartate receptor agonist that can produce excitotoxic neuron damage. Type I and II interferons (IFNs) stimulate the KYN/TRP pathway, producing elevated QA/kynurenic acid (KA), a potential neuro...

詳細記述

書誌詳細

出版年:	Lupus Science and Medicine
主要な著者:	Richard A Furie, Betty Diamond, Bruce Volpe, Ying Jin, Andrew Shih, Arnon Arazi, Erik W Anderson, Julien Roeser, Sara Goodwin
フォーマット:	論文
言語:	英語
出版事項:	BMJ Publishing Group 2022-07-01
オンライン･アクセス:	https://lupus.bmj.com/content/9/1/e000808.full