Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy (IgH) locus. During CSR, transcription through specific switch (S) regions and processing of non-coding germline transcripts (GLTs) ar...

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書誌詳細

出版年:	Frontiers in Immunology
主要な著者:	Anne Marchalot, Mohamad Omar Ashi, Jean-Marie Lambert, Claire Carrion, Sandrine Lecardeur, Nivine Srour, Laurent Delpy, Soazig Le Pennec
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2020-05-01
主題:	B cells class switch recombination splicing germline transcripts I exon antisense oligonucleotides
オンライン･アクセス:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00780/full