Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride

Sinomenine (SIN) is the key bioactive alkaloid isolated from Sinomenium acutum which has been prescribed commonly in Chinese medicine for managing rheumatic disorders. Despite its clinical relevance, the metabolic mechanisms underlying its therapeutic effects remain insufficiently explored, particul...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Gejing Li, Zhaoli Su, Yuanyuan Tang, Hong Huang, Junlan Zhang, Ye Lin, Qin Zhang, Xiong Cai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	rheumatoid arthritis sinomenine hydrochloride metabolomics adjuvantinduced arthritis glutamine synthetase
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1658089/full