Multiplex spatial omics reveals changes in immune-epithelial crosstalk during inflammation and dysplasia development in chronic IBD patients

Summary: Patients with long-standing inflammatory bowel disease (IBD) face an increased risk of developing colitis-associated cancer (CAC). Although IBD-induced prolonged inflammation seems to be involved in CAC pathogenesis, the specific molecular changes that contribute remain unknown. Here, we ap...

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Bibliographic Details

Published in:	iScience
Main Authors:	Matthijs J.D. Baars, Evelien Floor, Neeraj Sinha, José J.M. ter Linde, Stephanie van Dam, Mojtaba Amini, Isaäc J. Nijman, Joren R. ten Hove, Julia Drylewicz, G.Johan A. Offerhaus, Miangela M. Laclé, Bas Oldenburg, Yvonne Vercoulen
Format:	Article
Language:	English
Published:	Elsevier 2024-08-01
Subjects:	disease biopsy sample components of the immune system bioinformatics expression study transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224017759