APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

Abstract Introduction Hippocampal volume (HV) and cortical thickness are commonly used imaging biomarkers in Alzheimer's disease (AD) trials, and may have utility as selection criteria for enrichment strategies. Atrophy rates of these measures, in the high‐risk apolipoprotein E (APOE) ε4/ε4 hom...

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出版年:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
主要な著者:	Susan Abushakra, Anton P. Porsteinsson, Marwan Sabbagh, Luc Bracoud, Joel Schaerer, Aidan Power, John A. Hey, David Scott, Joyce Suhy, Martin Tolar, for the Alzheimer's Disease Neuroimaging Initiative
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2020-01-01
主題:	ALZ‐801 Alzheimer's disease amyloid beta amyloid oligomers apolipoprotein E ε4/ε4 homozygotes biomarkers
オンライン･アクセス:	https://doi.org/10.1002/trc2.12117