MicroRNA-21 Negatively Regulates Treg Cells Through a TGF-β1/Smad-Independent Pathway in Patients with Coronary Heart Disease

Background: CD4+CD25+FoxP3+ regulatory T cells (Treg cells) play a protective role against the development and progression of the inflammatory disease atherosclerosis (AS). MicroRNA-21 (miR-21) is expressed in Treg cells and is up-regulated in the context of AS and other inflammatory diseases. Aims:...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Sihui Li, Qian Fan, Shaolin He, Tingting Tang, Yuhua Liao, Jiangjiao Xie
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Subjects:	MiR-21 Treg cells TGF-β1 Coronary heart disease Smad7
Online Access:	http://www.karger.com/Article/FullText/430214